A Gene Encoding a Homologue of Dolichol Phosphate- -D-Mannose Synthase Is Required for Infection of Streptomyces coelicolor A3(2) by Phage C31
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چکیده
We have shown previously that a gene encoding a homologue to the eukaryotic dolichol-phosphate-Dmannose, protein O-D-mannosyltransferase, was required for C31 infection of Streptomyces coelicolor. Here we show that a gene encoding the homologue to dolichol-phosphate-mannose synthase is also essential for phage sensitivity. These data confirm the role of glycosylation in the phage receptor for C31 in S. coelicolor.
منابع مشابه
Disruption of the GDP-mannose synthesis pathway in Streptomyces coelicolor results in antibiotic hyper-susceptible phenotypes.
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تاریخ انتشار 2002